Feature
Regenerative Options
All three are autologous (from your own blood)
PRPPlatelet-Rich Plasma
Liquid PRFInjectable PRF / i-PRF
Gel PRFPRF Bio-Filler
Processing
Typically spun to concentrate platelets within plasma for topical use or injection depending on protocol.
Often prepared using lower-speed protocols to retain more fibrin-building components that form a scaffold after placement.
Processed and then warmed/cooled to create a thicker gel matrix that can be placed where soft support is desired.
Additives
Tube system may include anticoagulant depending on protocol and intended use.
Frequently prepared without anticoagulant (protocol-dependent); intended to clot naturally after placement.
Autologous matrix; no synthetic filler or cross-linking chemicals.
Consistency
Thin liquid; commonly paired with microneedling or injected in targeted areas.
Serum-like at placement; may thicken into a soft fibrin matrix shortly afterward.
Gel-like, moldable; designed for gentle, natural-looking soft support.
Release Pattern
Often discussed as a more front-loaded release early after treatment.
Often discussed as scaffold-supported signaling over several days as fibrin remodels.
Combines soft support with a gradual signaling profile over days to weeks (area/protocol-dependent).
Best For
Skin quality support, microneedling add-on, select scar/hair protocols.
Under-eye quality support, fine-line areas, hair protocols, “booster” planning.
Natural-appearing soft support for select areas + tissue quality support (candidacy-dependent).
Typical Timeline
Commonly discussed as ~1–3 weeks for “brighter” look; collagen-focused change can build over ~4–12+ weeks.
Often gradual over ~2–8+ weeks with cumulative change across a series (plan-dependent).
May look subtly fuller early; refinement can continue over ~2–12+ weeks (area-dependent).
Typical Plan
Often a series (commonly ~3 sessions) with maintenance as recommended.
Often a series (commonly ~2–3 sessions) with maintenance as recommended.
Often a planned series (commonly ~2–3 sessions), depending on goals and area.
Downtime
Commonly mild redness/sensitivity ~1–3 days (longer if paired with deeper microneedling).
Possible temporary puffiness/tenderness ~1–3 days; bruising risk varies by area.
Swelling/fullness and occasional bruising can occur; many settle within ~2–7 days depending on area.